| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject novel compound that manifests strong cell- protecting action against the cytotoxicity caused by oxidized LDL in the kidney- originating cells and is useful for treatment or prevention of chronic renal failure and diabetic nephropathy and as an internal organ preservative. SOLUTION: This compound is represented by the formula (R1 is H, an acyl which may be substituted; R2 -R4 are each H, a lower alkyl, a lower alkenyl where both of them are not t-butyl, simultaneously; R<5> and R<6> are each H, an alkyl which may be substituted), typically 4,7-di -t-butyl-5 -hydroxy-2, 3- dihydrobenzofuran. This compound is prepared by adding dropwise methanesulfonic acid to a solution of 4-t -butyl-5 -hydroxy-2, 3-dihydrobenzofuran in a mixture of t-butyl alcohol with chloroform followed by extraction, washing and concentration of the product. |
