Derivatives of calcitonin-gene-related peptide fragment

摘要

New peptides derived from calcitonin-gene-related peptide (rCGRP- alpha ) (positions 27-37) sequence H-FVPTNVGSEAF-NH2 where: (i) 1-3 of the amino acids in the sequence FVPTNVGSE are replaced with K, Y, A, F, P, Hyp, S, L, Q, D, H, Acp, Pac, Tic, Hop, Aib, I or G; or (ii) the sequence FVPTNVGS is replaced with NFVPRSKISP, NVAPRSKISP, NVAPTNVGS or ILSSTNVGS; and/or (iii) 1-8 of the amino acids in the sequence FVPTNVGSE are deleted; and (iv) one amino acid in the sequence FVPTNVGSEAF can be a D-amino acid; and (v) the N-terminal amino group can be substituted by a protecting group R selected from 3,3-diphenylpropionyl, 2-propylpentanoyl, 3,5-dichlorophenoxyacetyl, 1-adamantylacetyl, 3,5-dibromo-4-hydroxyphenylalanyl, 4-(4-benzhydryl-1-piperazinyl)-1,5-dioxo-3,3-(tetramethylene)-pentyl or 5,11-dihydro-6-oxo-6H-dibenzb,eazepin-11-carbonyl. The peptide H-YVPTNVGSEAF-NH2 is excluded.