发明名称 |
TISSUE FIXATION WITH CROSS-LINKING COMPOUNDS |
摘要 |
Crosslinking to prepare fixed tissue or to crosslink modification molecules to tissue is carried out with an apparatus and method wherein diffusion through a semipermeable is used to provide a selected molecular weight distribution of oligomers of a crosslinking compound that polymerizes spontaneously in solution to produce oligomers such as glutaraldehyde. The membrane has a molecular weight exclusion limit that prevents oligomers above a certain molecular weight from passing. Tissues treated with the size selected oligomers have improved properties. In the apparatus, the membrane separates a solution containing the crosslinking compound and oligomers from a solution in which crosslinking is carried out. The selected molecular weight distribution of oligomers diffuses through the membrane into the solution where tissue is crosslinked or a beneficial molecule is crosslinked to tissue. |
申请公布号 |
WO9850082(A3) |
申请公布日期 |
1999.02.04 |
申请号 |
WO1998US08533 |
申请日期 |
1998.04.30 |
申请人 |
ST. JUDE MEDICAL, INC. |
发明人 |
OGLE, MATTHEW, F.;SCHROEDER, RICHARD, E. |
分类号 |
A61L27/36;A61L27/38 |
主分类号 |
A61L27/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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