[(BENZODIOXAN, BENZOFURAN OR BENZOPYRAN)-ALKYLAMINO]-ALKYLSUBSTITUTED GUANADIDINES AS SELECTIVE VESSEL CONSTRICTIVE MEANS

摘要

The compounds have the formula(formula)where X is -O-, CH2 or a direct bond, R1 is hydrogen or C1-6alkyl, R2 is hydrogen, C1-6 alkyl, C3-6 alkenyl or C3-6 alkynyl,R3 is hydrogen or C1-6 alkyl or R2 and R3 taken together form atwo-valent radical having the formula -(CH2)m- where m is 4 or 5,or R1 and R2 taken together form a two-valent radical having theformula -CH=CH- or -(CH2)n-, where n is 2, 3 or 4, or R3 can meana bond when R1 and R2, taken together, form a two-valent radicalwith the formula -CH=CH-CH=, -CH=CH-N= or -CH=N-CH=; R4 ishydrogen or C1-6 alkyl; Alk1 is two-valent C1-3 alkandyl radical,A is two-valent radical with the respective formula. The inventionalso relates to compositions including the guanadine derivativesas active ingredient, to the method for the preparation of thederivatives and to N-cyanoguanadine, its intermediate compoundsand their application as medicines.