发明名称 |
PROCESS FOR PREPARING AMINOARYLACETYLENES |
摘要 |
This invention provides a process for preparing aminoarylacetylenes comprising reacting an N-arylmethylidene aminoarylhalide with a terminal acetylene in the presence of a base and a catalyst system comprising a palladium catalyst and a cuprous salt to produce a novel N-arylmethylidene aminoarylacetylene, and hydrolyzing the N-arylmethylidene aminoarylacetylene to the aminoarylacetylene. In one embodiment, the invention provides a process for preparing aminophenylacetylenes comprising reacting an N-benzylidene aminophenylhalide with a terminal acetylene in the presence of a base and the catalyst system to produce a novel N-benzylidene aminophenylacetylene, and hydrolyzing the N-benzylidene aminophenylacetylene to the aminophenylacetylene. |
申请公布号 |
WO9903803(A2) |
申请公布日期 |
1999.01.28 |
申请号 |
WO1998US14253 |
申请日期 |
1998.07.08 |
申请人 |
CATALYTICA PHARMACEUTICALS, INC.;GRUBER, JOHN, M. |
发明人 |
GRUBER, JOHN, M. |
分类号 |
B01J31/24;B01J31/30;C07B61/00;C07C209/62;C07C211/45;C07C249/02;C07C251/24 |
主分类号 |
B01J31/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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