PROCEDE DE DEPISTAGE ET/OU DE PRONOSTIC D'UN CANCER PAR DETECTION D'UNE PROTEINE DU CYCLE DE TYROSINATION-DETYROSINATION DE LA TUBULINE AINSI QUE SES APPLICATIONS

摘要

The invention concerns a method for detection and/or prognosis of cancer by detecting a protein of the tubulin tyrosination-detyrosination cycle (absence of tubulin-tyrosin-ligase (TTL) and/or presence of tubulin DELTA 2) and a detection and/or prognosis kit (metastatic potentiality, invasive character, rate of tumour development) of a cancer. Said method consists in detecting, in a tissue sample or in a biological fluid, a protein of the tubulin tyrosination-detyrosination cycle, selected in the group consisting of tubulin-tyrosin-ligase and tubulin DELTA 2 and/or an antibody directed against one of these proteins.