| 摘要 |
The invention relates to a method for producing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides. In a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonic acid halogenides in the presence of an acid acceptor and a diluting agent at temperatures between 0 DEG C and 150 DEG C. In a second step, the N-(2-cyano-4,5-difluoro-phenyl)-sulphonamide and/or N-(2-cyano-4,5-difluoro-phenyl)-sulphonamides are reacted, either in the pure state or mixed, with ammonia in the presence of a diluting agent at temperatures between 100 DEG C and 200 DEG C. The invention also relates to new intermediate products of this method.
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| 申请人 |
BAYER AG, 51373 LEVERKUSEN, DE |
发明人 |
HUPPERTS, ACHIM, DIPL.-CHEM. DR., 40217 DUESSELDORF, DE;DREWES, MARK WILHELM, DR., 40764 LANGENFELD, DE;ERDMAN, DAVID, DR., 51061 KOELN, DE;LANTZSCH, REINHARD, DR., 42115 WUPPERTAL, DE |
