IMPLANTABLE DEVICE COATED WITH POLYMER CAPABLE OF RELEASING BIOLOGICALLY ACTIVE SUBSTANCES

摘要

The invention concerns the field of devices implantable in the system. The device comprises an electroconductive support coated with an electroconductive polymer deposit derived from pyrrole, naphthalene or thiopene, whereon is encapsulated at least one biologically active substance of anionic or cationic type, and in particular an oligonucleotide antisense. The polymer deposition on the support is carried out, in a first step, by electropolymerisation directly on the metal support, or in another embodiment, by deposition of the polymer in a solution on the metal support; then, in a second step, by oxidation or electrochemical reduction and fixing of the biologically active substance of anionic or cationic type on the polymer. The invention is applicable in cardiology for preparing stents for treating restenosis.