发明名称 |
DERIVATIVES OF POLYSUBSTITUTED 2-AMIDO-4-PHENYLTHIAZOLES, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS FOR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
摘要 |
FIELD: chemistry of heterocyclic compounds. SUBSTANCE: invention relates to compounds of the formula (I) <EMI ID=0.224 HE=18 WI=36 TI=CHI> where Y means 3-quinolinyl group or 2-indolyl group of the formula (II) <EMI ID=0.225 HE=24 WI=30 TI=CHI> where R means hydrogen, acetyl group or group <EMI ID=0.226 HE=6 WI=15 TI=CHI> being <EMI ID=0.227 HE=3 WI=3 TI=CHI> means hydrogen or C<SB>1</SB>-C<SB>4</SB>-alkyl; X means (hetero)aryl radical taken from a group given in description; Z means hydrogen, C<SB>1</SB>-C<SB>4</SB>-alkyl or benzyl, and their salts and solvates also. Invention relates to also a method of synthesis of compounds of the formula (I), intermediate compounds for synthesis and a pharmaceutical composition based on compounds said. Synthesized compounds show agonism with respect to cholecystokinin receptors and can be used for treatment of patients with disorders caused by cholecystokinin. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 12 cl, 4 tbl, 34 ex
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申请公布号 |
RU2125569(C1) |
申请公布日期 |
1999.01.27 |
申请号 |
RU19940004997 |
申请日期 |
1994.02.18 |
申请人 |
ELF SANOFI |
发明人 |
ROBER BUAZHEGREHN;ROZHE BRODEN;DANIEL' FREEHL';DANIELL' GJULLI;ZHAN-SHARL' MOLIMARD;DOMINIK OLLIERO |
分类号 |
A61K31/404;A61K31/425;A61K31/427;A61K31/44;A61K31/47;A61K31/4709;A61K31/505;A61P1/00;A61P3/08;A61P25/00;A61P25/18;C07D277/40;C07D417/04;C07D417/12;C07D417/14;(IPC1-7):C07D417/12 |
主分类号 |
A61K31/404 |
代理机构 |
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地址 |
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