| 摘要 |
FIELD: organic chemistry, virology. SUBSTANCE: invention relates to new derivatives of phenoxy- or phenoxyalkylpiperidine of the formula (I) <EMI ID=0.214 HE=27 WI=48 TI=CHI> where R<SB>1</SB>- are <EMI ID=0.215 HE=21 WI=60 TI=CHI> or <EMI ID=0.216 HE=18 WI=21 TI=CHI> and R<SB>4</SB>- are <EMI ID=0.217 HE=15 WI=48 TI=CHI> or <EMI ID=0.218 HE=18 WI=21 TI=CHI>; R<SB>2</SB> and R<SB>3</SB> - hydrogen, lower alkyl or halogen; R<SB>5</SB> and R<SB>6</SB> - hydrogen, lower alkyl, halogen; R<SB>7</SB> - hydrogen or lower alkyl; R<SB>8</SB> - hydrogen, lower alkyl, trifluoromethyl; R<SB>9</SB> - lower alkyl; R<SB>10</SB> - lower alkyl, difluoromethyl, trifluoromethyl; Y - a covalent bond, lower alkylene, or their salts. Invention relates to also an antiviral composition based on compounds of the formula (I) taken at effective doses that can be used in medicine for treatment and prophylaxis of patients with viral infection. Compounds of the formula (I) are synthesized by interaction of (I)-R<SB>1</SB>-4-hydroxy-, (I)-R<SB>1</SB>-4-hydroxyalkylpiperidine of the formula (II) <EMI ID=0.219 HE=18 WI=33 TI=CHI> with phenol of the formula (III) <EMI ID=0.220 HE=24 WI=30 TI=CHI> in the presence of triphenylphosphine and diethylazo- -dicarboxylate in inert solvent. EFFECT: improved method of synthesis. 9 cl, 3 tbl, 17 ex
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