Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
申请公布号
US5864009(A)
申请公布日期
1999.01.26
申请号
US19950480478
申请日期
1995.06.06
申请人
CORVAS INTERNATIONAL, INC.
发明人
VLASUK, GEORGE PHILLIP;STANSSENS, PATRICK ERIC HUGO;MESSENS, JORIS HILDA LIEVEN;LAUWEREYS, MARC JOZEF;LAROCHE, YVES RENE;JESPERS, LAURENT STEPHANE;GANSEMANS, YANNICK GEORGES JOZEF