发明名称 |
Process for the manufacture of 3-amino-substituted glycosylated bile acids |
摘要 |
The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Intermediates and related compounds are also disclosed. In particular, the present invention permits the conversion of cholic acid esters to the 3-amino-7,12-bis(glucosyl)cholic acid esters via an azide intermediate. Conditions for the purification and isolation of the desired product is also disclosed to provide an overall manufacturing process suitable for large-scale production.
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申请公布号 |
US5864022(A) |
申请公布日期 |
1999.01.26 |
申请号 |
US19970822849 |
申请日期 |
1997.03.24 |
申请人 |
INTERCARDIA, INC. |
发明人 |
CHEN, ANNA K.;KAKARLA, RAMESH;LIU, DASHAN;SOFIA, MICHAEL J.;ZEBOVITZ, THOMAS C. |
分类号 |
C07G3/00;C07G99/00;C07H15/18;C07J3/00;C07J9/00;C07J17/00;C07J31/00;C07J41/00;(IPC1-7):C07J3/00;C07G17/00 |
主分类号 |
C07G3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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