| 摘要 |
PROBLEM TO BE SOLVED: To easily obtain the subject derivative in a short process without the need of intermediate isolation, by reaction between each specific aldehyde, primary amine and silyl cyanide in the presence of a specific catalyst. SOLUTION: This aminonitrile derivative of formula II is obtained by reaction at -40 to 100 deg.C between (A) an aldehyde of the formula R<1> -CHO [R<1> is a (substituted) alkyl, cycloalkyl, alkenyl, aralkyl, aryl, acyl or heterocycle], (B) 0.9-1.5 mol, per mol of the component A, of a primary amine of the formula R<2> -NH2 [R<2> is a (substituted) alkyl, cycloalkyl, aralkyl or aryl], and (C) 0.9-1.5 mol, per mol of the component A, of a silyl cyanide of formula I (R<3> to R<5> are each an organic group), in the presence of (D) 0.0001-0.5 mol, per mol of the component A, of an ytterbium triflate catalyst; wherein a dehydrating agent (e.g. molecular sieve) may coexist in the reaction system. |
