EXTRACTION OF TAXANES BY ION EXCHANGE MEDIA

摘要

The present invention is a method that uses an absorption column for the cleavag e and recovery of taxanes, which are not normally detected as free taxanes. The method processes a first solution that contains st andard detectable taxanes and other undetectable taxane compounds to generate a second solution that contains a higher percentage of det ectable standard taxane then the first solution. The first step of this method is loading a column having a first opening and a second open ing with an ion exchange media. The next step is placing the first solution in the first opening of the column so that the first solution passes through the ion exchange media in the column and flows to the second opening. Thus, the taxane compounds are converted to standard taxa nes by an ion exchange reaction and the second solution is formed. Then the next step is collecting, from the second opening of the colu mn, the second solution and recovering from the second solution a larger percentage of standard taxanes then was detectable in the firs t solution. The ion exchange media of the present solution is an ion exchange resin. The ion exchange resin can be a mixture of an anion ex change resin and a cation exchange resin. The anion exchange resin is in the OH- form. The cation exchange resin is in the H+ form. Preferably, the ion exchange resin is alumina.