SEMI-SYNTHETIC GLYCOSAMINOGLYCANS WITH HEPARIN OR HEPARAN STRUCTURE OF ALPHA-L-IDURONIC-2-SULFATE ACID MODIFIED IN POSITION 2

摘要

The synthesis of new semi-synthetic glycosaminoglycans with heparin or heparan structure of .alpha.-L-iduronic-2-O-sulfate acid modified in position 2 is described in which the sulfate group is, entirely or in part, substituted with a nucleophilic radical. These new semi-synthetic glycosaminoglycans of general formula have good pharmaceutical properties in that they may also be absorbed orally and have good anti-thrombotic activity accompanied by low risk of haemorrhage and reduced anti-coagulating activity.