发明名称 |
An improved method for design and selection of efficacious antisense oligonucleotides |
摘要 |
The invention includes methods for predicting whether an antisense oligonucleotide (ASO) will be efficacious for inhibiting expression of a gene. The invention also includes methods of making efficacious ASOs, comprising a 5'-TCCC-3' motif or another chemical entity which is capable of Watson-Crick-type base-pairing with a 5'-GGGA-3' motif in an RNA molecule such as a primary transcript or an mRNA. The invention further includes ASOs which are useful for inhibiting expression of one of tumor necrosis factor-a in a mammal. Methods of treating an animal comprising a disease or disorder which is characterized by the presence of an RNA molecule in a cell of the animal are also included. |
申请公布号 |
AU8280798(A) |
申请公布日期 |
1999.01.25 |
申请号 |
AU19980082807 |
申请日期 |
1998.07.02 |
申请人 |
THOMAS JEFFERSON UNIVERSITY |
发明人 |
GUANG-CHOU TU;YEDI ISRAEL |
分类号 |
A61K38/00;C12N15/113 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|