| 发明名称 |
Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| 摘要 |
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula II having the structure: wherein X4, X5; R1, R2; and Ar and n are as described in the specification. |
| 申请公布号 |
ZA9806208(B) |
申请公布日期 |
1999.01.25 |
| 申请号 |
ZA19980006208 |
申请日期 |
1998.07.13 |
| 申请人 |
ADOLOR CORPORATION. |
发明人 |
LAWRENCE I. KRUSE;AN-CHIH CHANG;DIANE L. DEHAVEN-HUDKINS;JOHN J. FARRAR;FORREST GAUL;VIRENDRA KUMAR;MICHAEL ANTHONY MARELLA;ALAN L. MAYCOCK;WEI YUAN ZHANG |
| 分类号 |
C07D295/12;A61K31/40;A61K31/404;A61K31/405;A61K31/4427;A61K31/4439;A61K31/495;A61K31/496;A61P17/04;A61P25/04;C07D207/09;C07D207/12;C07D209/08;C07D209/18;C07D209/42;C07D213/56;C07D241/04;C07D273/08;C07D401/12;C07D403/06;C07D403/12 |
主分类号 |
C07D295/12 |
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