摘要 |
The present invention relates to a histidine kinase, two-component gene (CaHK1) from Candida albicans. CaHK1 encodes a 2471 amino acid protein with an estimated molecular mass of 281.8 kDa. Also provided are vectors, host cells, antibodies and recombinant methods for producing the same. The invention further relates to agonists and antagonists and to screening methods for identifying agonists and antagonists of CaHK1 polypeptide activity. The invention additionally relates to diagnostic methods for detecting CaHK1 nucleic acids, polypeptides, and antibodies in a biological sample. The present invention further relates to novel antagonists and vaccines for the prevention or attenuation of infection by Candida albicans.
|
申请人 |
HUMAN GENOME SCIENCES, INC.;GEORGETOWN UNIVERSITY;CHOI, GIL, H.;CALERA, JOSE, A.;CALDERONE, RICHARD, A. |
发明人 |
CHOI, GIL, H.;CALERA, JOSE, A.;CALDERONE, RICHARD, A. |