Nitric oxide generating compounds or compounds which induce in situ synthesis of nitric oxide can be used to inhibit rhinovirus infection. Nitric oxide has the ability to inhibit both viral replication as well as the synthesis of cytokines, in particular the proinflammatory cytokines. Thus the symptoms of rhinovirus infections can be ameliorated by treatments to increase nitric oxide in the respiratory tract.
申请公布号
WO9902148(A1)
申请公布日期
1999.01.21
申请号
WO1998US14466
申请日期
1998.07.10
申请人
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;SANDERS, SCHERER, P.;PROUD, DAVID