发明名称 |
ANTIBODIES AND SCFV IMMUNOTOXINS SPECIFIC TO IMPORTED FIRE ANTS, AND THEIR APPLICATION |
摘要 |
The present invention is drawn to a safe, cost-effective, environmentally-friendly and ecologically-sound bioengineered product for managing imported fire ants, and a method of making this product. Immunological and genetic engineering techniques are used to generate monoclonal antibodies (mAbs) as well as viruses (phage) that display scFv heavy and/or light chain Ig fragments which exhibit high-avidity specific binding to cells of the microvilli of the midgut of imported fire ant queens. The specific monoclonal antibodies and phage displayed antibody Fab fragments are conjugated to a toxin for targeted delivery and destruction of imported fire ant queens, but not native species, thereby restoring the natural ecosystem.
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申请公布号 |
WO9902991(A1) |
申请公布日期 |
1999.01.21 |
申请号 |
WO1998US14216 |
申请日期 |
1998.07.09 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
SANDERS, ROBERT;KLINE, KIMBERLY |
分类号 |
G01N33/53;A01N61/00;A61K38/00;A61K39/395;C07K16/00;C07K16/18;C07K16/28;C07K16/44;C07K19/00;C12N5/18;C12N15/02;C12N15/09;C12P21/00;C12P21/08;(IPC1-7):G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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