发明名称 RESOLUTION OF AMINES
摘要 The process comprises reacting the mixture consisting of 2-¢phenyl(1-methyl-1H-pyrazol-5-yl)methoxy!-N,N-dimethyl-etanamine (I) with an enanthiomer of an optically active acid in order to form a diasteroisomer salt, separating said salt and releasing the enantiomer from said compound (I). The dextrorotatory enantiomer of (I) can be obtained by reacting a racemic or non racemic mixture of (I) with (')-ditoluyl-L-tartaric acid, optionally mixed with ptoluensulfonic acid. The compound (I) has analgesic properties and its most active enantiomer is the destorotatory enantiomer.
申请公布号 CA2295800(A1) 申请公布日期 1999.01.21
申请号 CA19982295800 申请日期 1998.07.06
申请人 LABORATORIOS DEL DR. ESTEVE, S.A. 发明人 FRIGOLA-CONSTANSA, JORDI;TORRENS-JOVER, ANTONI
分类号 A61K31/415;A61P29/00;C07D231/12;(IPC1-7):C07D231/12 主分类号 A61K31/415
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