摘要 |
Compounds represented by general formula (I), salts thereof and type N calcium channel inhibitors containing the same as the active ingredient, wherein R<1> represents optionally substituted alkyl, alkoxy or phenyl, a heterocyclic group, etc.; A represents a single bond, CO or SO2; R<2> represents H, optionally substituted alkyl, etc.; D represents alkylene, etc.; E represents COO, OCO, O, S, SO, SO2, etc.; R<3> represents optionally substituted alkyl, a carbocyclic group or a heterocycle group; J represents O or NR<16> (wherein R<16> represents H or optionally substituted alkyl); and R<4> represents optionally substituted alkyl, a carbocyclic group or a heterocyclic group. Because of inhibiting the type N calcium channel, the compounds (I) are useful as preventives and/or remedies for cerebral infarction, transient cerebral ischemic attack, cerebrospinal disorders following heart operations, spinal vascular lesion, stress hypertension, neurosis, epilepsy, etc. or remdies for pains.
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