SIDE CHAIN TAXANES, INTERMEDIATE COMPOUNDS, AND METHODS OR PREPARING, THEREOF

摘要

FIELD: medicine. SUBSTANCE: present invention describes side chain taxanes and intermediates thereof and novel compounds of formula III. Oxazoline side taxanes of formula III: R wherein R , is phenyl, alkyl, alkenyl, alkoxy; R is H; R is phenyl, benzyl or furyl; R and R14O are H, OH or R ; R and C3-7 are independently hydrogen, alkyl, alkenyl, R -cycloalkyl, phenyl; is hydroxy protecting group, and salts thereof show antitumor activity. EFFECT: improved properties of the title compounds. 81 cl, 86 ex