| 摘要 |
A method of preparing a chiral compound, involves: (1) Synthesis of an alkenyl oxy-aryl or alkenyl aryl-oxy-aryl bifunctional compound of formula: ÄR-CH=CH-(X)-OÜn-Ar-Q ; (where: Q = group that will react with the H carried by a heteroatom (O, N, S) or a precursor of such a group; n = 1 - 20; R = H-alkyl, alkoxy, OH, or aryl, optionally substituted; X = divalent alkyl having ≥ 1 C atom, or an aryl optionally substituted by alkyl, alkoxy, OH, or trihaloalkyl; Ar = aryl or polyaryl, optionally substituted with alkyl, alkoxy, OH, trihaloalkyl, silyl, thiol, aminoalkyl, amido, nitro, nitro-amino, N-amino, aldehyde, acid, or ester; (2) Reacting ≥ H on an alcohol, amine, or thiol function of a chiral unit with the group (Q) on the bifunctional compound. Also claimed is: (i) a process for the synthesis of polymers in which a bifunctional compound as described above, where specifically: Q = -NCO or its precursor, -NH2, -CON3, -COCl or its precursor, -COOH, -NCS, or -CH2-Y; Y = Cl, Br , I, methyl sulphonyl oxy, p-toluene sulphonyl oxy, or 3,5-dimethyl phenyl sulphonyl oxy; is synthesised, followed by polymerisation of the alkenyl group or the group R1 (sic) to give a polymer functionalised with group Q; (ii) Bifunctional compounds as described; (iii) Chiral compounds as described, physically deposited on a support; and (iv) Process for separating chiral compounds, or for the preparation of enantiomers, or for asymmetric synthesis, using chiral compound deposited on a support, using liquid chromatography, gas chromatography, supercritical chromatography, subcritical chromatography, centrifuge division chromatography, electrophoresis, electro-chromatography, and any membrane separation process. |
