摘要 |
FIELD: organic chemistry. SUBSTANCE: invention proposes new compounds of the formula (I): <EMI ID=0.134 HE=15 WI=39 TI=CHI> where: X means arbitrarily substituted benzimidazole group; Y means oxygen or sulfur atom; Z means 2,4-dioxothiazolidine-5-yl-indenylmethyl, 2,4-dioxo- -thiazolidine-5-yl-methyl, 2,4-dioxooxazolidine-5-yl-methyl, 3,5-dioxooxadiazolidine-2-yl-methyl or N-hydroxyureidomethyl group; R - hydrogen, alkyl, alkoxy, halide, hydroxy, nitro, amino or aralkyl-group; m = 1-5. Invention claims also a pharmaceutical composition based on compounds of the formula (I) taken at effective amount and containing an acceptable carrier or vehicle. Synthesized compounds show hypoglycaemic activity and capability to inhibit activity of aldosoreductase and 5-lipoxygenase and lipid peroxide production also. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 23 cl, 7 tbl, 7 ex
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