| 摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) <EMI ID=0.126 HE=36 WI=48 TI=CHI> and (II) <EMI ID=0.127 HE=54 WI=24 TI=CHI> where R means hydrogen; R means alkyl, amino-group or substituted amino-group; R means optionally substituted phenyl; R means hydrogen, halogen or optionally substituted alkyl; R means hydrogen, optionally substituted alkyl, aryl or aralkyl. Synthesized compounds show analgetic, antiinflammatory activity and capability to inhibit leukotriene production, bone resorption and selective inhibition of COX-2 activity. Invention proposes also a pharmaceutical composition based on compounds said. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 17 cl, 130 ex, 13 tbl
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