发明名称 |
Liquid phase peptide syntheses of KL-4 pulmonary surfactant protein |
摘要 |
The invention realtes to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the alpha-carbon. |
申请公布号 |
ZA9706305(B) |
申请公布日期 |
1999.01.19 |
申请号 |
ZA19970006305 |
申请日期 |
1997.07.16 |
申请人 |
ORTHO PHARMACUETICAL CORPORATION. |
发明人 |
AHMED F. ABDEL-MAGID;URS EGGMANN;CYNTHIA A. MARYANOFF;ADRIAN THALER;FRANK J. VILLANI |
分类号 |
A61K38/00;C07K1/12;C07K5/083;C07K5/09;C07K14/785 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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