发明名称 |
Chimeric proteins comprising a Vpr/Vpx virion incorporation domain for targeting into HIV-1 or HIV-2 virions |
摘要 |
The present invention is directed toward chimeric human immunodeficiency virus type 1 and 2 (HIV-1 and -2) proteins that are capable of being incorporated into the virion when expressed in trans. These chimeric proteins consist of a first portion comprising an HIV-1 or HIV-2 Vpr/Vpx virion incorporation domain which includes the predicted N-terminal alpha helix. This domain is capable of interacting with the p6 domain of the Pr55gag. The second portion of the chimera comprises a sequence containing RNase activity, protease activity, or a domain capable of inhibiting virion morphogenesis and assembly. The disclosed invention provides a chimera that affects the structural organization or functional integrity of the mature virion by enzymatic disturbance or steric hindrance of the virion.
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申请公布号 |
US5861161(A) |
申请公布日期 |
1999.01.19 |
申请号 |
US19940301915 |
申请日期 |
1994.09.07 |
申请人 |
UNIVERSITE DE MONTREAL |
发明人 |
COHEN, ERIC A.;BERGERON, DOMINIQUE;CHECROUNE, FLORENT;YAO, XIAO-JIAN;PIGNAC-KOBINGER, GARY |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K39/21;A61K48/00;A61P31/12;C07K14/155;C07K14/16;C07K19/00;C12N9/52;C12N9/62;C12N9/64;C12N9/99;C12N15/49;C12N15/57;C12N15/867;(IPC1-7):A61K39/00;C07K1/00 |
主分类号 |
C12N15/09 |
代理机构 |
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主权项 |
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