Antisense oligonucleotides to inhibit expression of mutated and wild type genes for collagen

摘要

PCT No. PCT/US93/10756 Sec. 371 Date Jun. 30, 1995 Sec. 102(e) Date Jun. 30, 1995 PCT Filed Nov. 9, 1993 PCT Pub. No. WO94/11494 PCT Pub. Date May 26, 1994The present invention is directed to oligonucleotides that inhibit mutant COL1A1 and/or wild type COL1A1 gene expression. The present invention is further directed to methods of inhibiting mutant and/or wild type collagen gene expression using the disclosed inhibitory oligonucleotides. The oligonucleotides and methods of the present invention are useful for the treatment of mammals having diseases related to inappropriate mutant or wild type COL1A1 gene expression.