发明名称 13-substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests
摘要 Compounds of formula (I): <IMAGE> (I) <IMAGE> wherein: R1 is methyl, ethyl, isopropyl or sec-butyl; X is carbonyl or methylene; Z is =C=(R2)2 or =C=(CH2)m, in which R2 is alkyl, and m is integer of from 2 to 5); n is 0 or 1; R3 is nitro, amino, alkylamino, dialkylamino, alkoxy, alkoxyalkoxy, or a group (iii), (iv), (v), (vi), (vii), (viii) or (ix): <IMAGE> (iii) <IMAGE> (iv) <IMAGE> (v) <IMAGE> (vi) <IMAGE> (vii) <IMAGE> (viii) <IMAGE> (ix) , wherein: R4 represents: alkyl; substituted alkyl; cycloalkyl having from 3 to 6 carbon atoms; substituted cycloalkyl; alkenyl; alkynyl; carbocyclic aryl; or heterocyclic; R5 is hydrogen atom or alkyl; R6 represents: hydrogen; alkyl; or cycloalkyl; R7 represents: alkyl; cycloalkyl; carbocyclic aryl; or aralkyl; or R6 and R7, together with the nitrogen atom to which they are attached, are fuised to form heterocyclic ring; Y is oxygen or sulfur; r is 1, 2 or 3; Q is methylene or carbonyl; R8 is: alkyl or carbocyclic aryl; R9 is: alkyl; cycloalkyl; carbocyclic aryl; or aralkyl; R10 is heterocyclic; and R11 is aLkyl; have valuable acaricidal, insecticidal and anthelmintic activities.
申请公布号 US5861429(A) 申请公布日期 1999.01.19
申请号 US19960723835 申请日期 1996.09.30
申请人 SANKYO COMPANY, LIMITED 发明人 SATO, KAZUO;SAITO, AKIO;TOYAMA, TOSHIMITSU
分类号 C07D493/22;A01N43/08;A01N43/16;A01N43/90;A61K31/343;A61K31/35;A61P31/14;A61P33/10;C07D307/26;C07D311/96;C07D313/00;C07H19/01;(IPC1-7):A61K31/335;A61K31/38;A61K31/505;A61K31/425 主分类号 C07D493/22
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