Arylsulfonyl hydroxamic acid derivatives as MMP and TNF inhibitors

摘要

PCT No. PCT/IB95/00279 Sec. 371 Date Oct. 7, 1997 Sec. 102(e) Date Oct. 7, 1997 PCT Filed Apr. 20, 1995 PCT Pub. No. WO96/33172 PCT Pub. Date Oct. 24, 1996A compound of the formula <IMAGE> I wherein R1, R2 R3, R4 R5, R6, R7, R8, R9 and Ar are as defined above, useful in the treatment of a condition seiected from the group consisting of arthritis, cancer, tisuue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other disease characterized by matrix metalloproteinase activity, as well as AIDS, sepsis, septic shock and other diseases involving the production of TNF.