发明名称 |
TREATMENT OF TUMORIGENIC PATHOPHYSIOLOGICAL CONDITIONS WITH FGF-CYTOTOXIC CONJUGATES |
摘要 |
Conjugates comprising bFGF or other FGF polypeptides and cytotoxic agent are pre pared. The cytotoxic agent can be a ribosome-inactivating protein (RIP), such as saporin, which is attached to bFGF through a chemical bond, or the composition can be prepared as a recombinant DNA chimera. The conjugates are used to specifi cally target cells, in vivo and in vitro, which express FGF receptors. The cytotoxicity of the conjugates is proportional to the number of receptors expressed by a cell type. The conjugate is useful to effectively treat mammals, and in particular human patien ts, afflicted with tumorigenic conditions, such as human melanomas, human ovarian carcinomas, teratocarcinomas and neurobiastomas, and other FGF-mediated tumors caused by a proliferation of cells which express FGF receptors.
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申请公布号 |
CA2089820(C) |
申请公布日期 |
1999.01.19 |
申请号 |
CA19912089820 |
申请日期 |
1991.09.13 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES;ROGER WILLIAMS GENERAL HOSPITAL |
发明人 |
CALABRESI, PAUL;BEITZ, JULIE G.;CLARK, JEFFREY W.;FRACKELTON, A. RAYMOND JR.;LAPPI, DOUGLAS A.;BAIRD, J. ANDREW |
分类号 |
A61K38/22;A61K38/00;A61K47/48;A61P35/00;(IPC1-7):A61K47/48;A61K38/18 |
主分类号 |
A61K38/22 |
代理机构 |
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