发明名称 |
Genetic construct of which protein coding DNA comprises introns and is designed for protein production in transgenic animals |
摘要 |
Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5'-flanking sequence from a mammalian milk protein gene (such as beta-lactoglobulin) and DNA coding for a heterologous protein other than the milk protein (for example a serin protease such as alpha1-antitrypsin or a blood factor such as Factor VIII or IX). The protein-coding DNA comprises at least one, but not all, of the introns naturally occurring in a gene coding for the heterologous protein. The 5'-flanking sequence is sufficient to drive expression of the heterologous protein.
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申请公布号 |
US5861299(A) |
申请公布日期 |
1999.01.19 |
申请号 |
US19940343884 |
申请日期 |
1994.11.17 |
申请人 |
PPL THERAPEUTICS (SCOTLAND) LIMITED |
发明人 |
ARCHIBALD, ALAN LANGSKILL;CLARK, ANTHONY JOHN;HARRIS, STEPHEN;MCCLENAGHAN, MARGARET;SIMONS, JONATHAN PAUL;WHITELAW, CHRISTOPHER BRUCE ALEXANDER |
分类号 |
A01K67/027;C07K14/47;C07K14/81;C12N1/21;C12N5/10;C12N9/64;C12N15/00;C12N15/09;C12N15/57;C12N15/67;C12N15/85;C12P21/02;C12R1/19;(IPC1-7):C12N5/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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