摘要 |
The invention is concerned with compounds of the general formula (see fig. I) wherein R1 signifies hydrogen, lower alkyl, phenyl orbenzyl, R2 signifies lower alkyl, lower alkoxy, -O(CH2)n N(R13)(R14), -(CH2)n N(R13)(R14) or -N(R15)(CH2)n N(R13)(R14), R3-R12 signify hydrogen, halogen, trifluoromethyl, lower alkyl, cycloalkyl, lower alkoxy, hydroxy, nitro, cyano, -N(R13)2, phenyl, phenyloxy, benzyl or benzyloxy, or R6 and R7 together signify a benzene ring, R13-R15 signify hydrogen, lower alkyl orcycloalkyl and n signifies 1-5, as well as their pharmaceutically acceptable salts. These compounds are suitable for the control or prevention of acute and/or chron ic neurological disorders such as restricted brain function caused by bypass operat ions or transplants, poor blood supply to the brain, spinal cord injuries, head injuries , hypoxia caused by pregnancy, cardiac arrest, hypoglycaemia, Alzheimer's disease,Huntingt on's chorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, cognitive disor ders, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditi ons which lead to glutamate-deficiency functions, such as e.g. muscle spasms, convul sions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety, vomiting, chronic pain, dyskinesia and depressions. |