发明名称 |
IMMUNOADHESINS AND METHODS OF PRODUCTION AND USE THEREOF |
摘要 |
The invention is directed toward a compound comprising a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid, wherein the recombinant nucleic acid can be packaged in an adenovirus particle and wherein expression of the recombinant nucleic acid encoding the immunoadhesin results in production of the immunoadhesin protein. The recombinant nucleic acid encoding the immunoadhesin can be within an adenovirus. The invention further provides methods for delivering an immunoadhesin to a cell or a subject comprising administering to the cell or the subject an adenovirus comprising a recombinant nucleic acid encoding an immunoadhesin; producing an immunoadhesin comprising administering to a cell an adenovirus comprising a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid, whereby the cell expresses the recombinant nucleic acid encoding the immunoadhesin, thereby producing the immunoadhesin; treating an inflammatory condition in a subject comprising administering to the subject an adenovirus comprising a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid or a recombinant nucleic acid encoding an immunoadhesin inserted within an adenoviral nucleic acid, whereby a cell in the subject expresses the recombinant nucleic acid encoding the immunoadhesin and produces the immunoadhesin, thereby treating the inflammatory condition or administering to the subject a recombinant nucleic acid encoding an immunoadhesin, or an immunoadhesin, wherein the immunoadhesin is selected from the group consisting of vIL-10-IgG, IL-13-IgG, LFA-IgG, IL-2ra-IgG, IL-1ra-IgG, mutant IL-4-IgG, VLA4-IgG, IL-2-IgG, TGF- beta 1-IgG, TGF- beta 1223,225-IgG, and VCAM-IgG; and methods of screening an immunoadhesin for bioactivity. |
申请公布号 |
WO9840498(A3) |
申请公布日期 |
1999.01.14 |
申请号 |
WO1998US04634 |
申请日期 |
1998.03.10 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;CSAKY, KARL, G.;ANGLADE, EDDY;SULLIVAN, DANIEL, M.;LAROCHELLE, WILLIAM |
发明人 |
CSAKY, KARL, G.;ANGLADE, EDDY;SULLIVAN, DANIEL, M.;LAROCHELLE, WILLIAM |
分类号 |
A61K38/00;A61K47/48;A61K48/00;C07K14/495;C07K14/54;C07K14/55;C07K14/705 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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