发明名称 DIAMINORHODAMINE DERIVATIVES
摘要 Compounds represented by general formula (1), and reagents containing the same for determining nitrogen monoxide (wherein R1 and R2 are amino groups bonded to the phenyl ring at positions adjacent to each other; R3, R4, R5 and R6 are each independently C1-C6 alkyl; R7, R8, R9 and R10 are each independently hydrogen, C1-C6 alkyl, allyl or halogeno; R11 is hydrogen or C1-C18 alkyl; and X- is an anion). The compounds react with nitrogen monoxide efficiently to produce fluorescent compounds which emit intensive fluorescence when irradiated with a long-wavelength excitation light. The fluorescent compounds are detectable in a fluorescence region wherein little influence of autofluorescence of cells is observed, and characterized in that the intensity of fluorescence is not lowered even under acid conditions.
申请公布号 CA2295880(A1) 申请公布日期 1999.01.14
申请号 CA19982295880 申请日期 1998.06.30
申请人 NAGANO, TETSUO 发明人 NAGANO, TETSUO;KOJIMA, HIROTATSU
分类号 A61K31/352;C07D249/04;C07D311/82;C07D311/88;C07D311/96;C07D493/10;G01N31/22;G01N33/00;(IPC1-7):C07D311/84;G01N33/52;G01N21/78 主分类号 A61K31/352
代理机构 代理人
主权项
地址