发明名称 |
1-AMINO-ALKYLCYCLOHEXANE NMDA RECEPTOR ANTAGONISTS |
摘要 |
Certain 1-amino-alkylcyclohexanes are systemically-active uncompetitive NMDA receptor antagonists having rapid blocking/unblocking kinetics and strong voltage-dependency and are therefore useful in the alleviation of conditions resulting from disturbances of glutamatergic transmission giving them a wide range of utility in the treatment of CNS disorders involving the same, as well as in non-NMDA indications, due to their immunomodulatory, antimalarial, anti-Borna virus, and anti-Hepatitis C activities and utilities. Pharmaceutical compositions thereof and a method of treating conditions which are alleviated by the employment of an NMDA receptor antagonist, as well as the aforementioned non-NMDA indications, and a method for the preparation of the active 1-amino-alkylcyclohexane compounds involved. |
申请公布号 |
WO9901416(A2) |
申请公布日期 |
1999.01.14 |
申请号 |
WO1998EP04026 |
申请日期 |
1998.06.24 |
申请人 |
MERZ + CO. GMBH & CO. |
发明人 |
GOLD, MARKUS;DANYSZ, WOJCIECH;PARSONS, CHRISTOPHER, GRAHAM, RAPHAEL;KALVINSH, IVARS;KAUSS, VALERJANS;JIRGENSONS, AIGARS |
分类号 |
A61P1/16;A61K31/13;A61K31/40;A61P31/12;A61P33/06;A61P37/02;A61P43/00;C07C211/17;C07C211/35;C07D295/135 |
主分类号 |
A61P1/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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