发明名称 |
COMBINATORIAL POLYKETIDE LIBRARIES PRODUCED USING A MODULAR PKS GENE CLUSTER AS SCAFFOLD |
摘要 |
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method. |
申请公布号 |
WO9849315(A3) |
申请公布日期 |
1999.01.14 |
申请号 |
WO1998US08792 |
申请日期 |
1998.04.30 |
申请人 |
KOSAN BIOSCIENCES, INC.;THE BOARD OF REGENTS OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
KHOSLA, CHAITAN;ASHLEY, GARY;FU, HONG;KAO, CAMILLA, M.;MCDANIEL, ROBERT |
分类号 |
C12N15/09;A61K31/335;A61K31/351;A61K31/7048;A61P31/04;C07B61/00;C07D309/10;C07D309/30;C07D309/32;C07D313/00;C07D313/18;C07D323/00;C07D493/10;C07H17/04;C07H17/08;C12M1/00;C12N1/21;C12N15/52;C12P17/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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