发明名称 Substituted N-[(Aminoiminomethyl or aminomethyl)-phenyl]propyl amides
摘要 The compounds according to the invention are substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides of formula I herein which exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are Factor Xa inhibitors. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, methods for their preparation and their use, which are for treating a patient suffering from, or subject to, conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.
申请公布号 ZA9805664(B) 申请公布日期 1999.01.13
申请号 ZA19980005664 申请日期 1998.06.29
申请人 RHONE-POULENC RORER PHARMACEUTICALS INC. 发明人 SCOTT I. KLEIN;KEVIN R. GUERTIN;ALFRED P. SPADA;HEINZ W. PAULS;YONG GONG;DANIEL G. MCGARRY
分类号 C07D249/04;A61K31/00;A61K31/165;A61K31/166;A61K31/195;A61K31/215;A61K31/216;A61K31/24;A61K31/335;A61K31/357;A61K31/36;A61K31/381;A61K31/397;A61K31/40;A61K31/403;A61K31/4035;A61K31/404;A61K31/415;A61K31/4164;A61K31/4184;A61K31/4196;A61K31/426;A61K31/433;A61K31/437;A61K31/44;A61K31/4406;A61K31/4409;A61K31/4436;A61K31/4439;A61K31/4545;A61K31/47;A61P7/00;A61P7/02;A61P43/00;C07C45/63;C07C205/06;C07C205/57;C07C229/28;C07C233/64;C07C251/02;C07C255/60;C07C257/18;C07C259/18;C07D205/08;C07D207/32;C07D207/325;C07D207/327;C07D209/08;C07D209/48;C07D213/40;C07D213/54;C07D213/55;C07D213/56;C07D213/57;C07D213/58;C07D213/70;C07D213/74;C07D213/82;C07D213/89;C07D215/04;C07D215/48;C07D231/14;C07D233/54;C07D233/56;C07D235/04;C07D235/06;C07D235/08;C07D249/06;C07D277/20;C07D277/28;C07D277/56;C07D285/08;C07D317/46;C07D317/60;C07D319/16;C07D319/18;C07D333/70;C07D401/04;C07D409/04;C07D417/04;C07D471/04;C07D521/00 主分类号 C07D249/04
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