发明名称 |
Methods for selectively stimulating proliferation of T cells |
摘要 |
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28 or CD9, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
|
申请公布号 |
US5858358(A) |
申请公布日期 |
1999.01.12 |
申请号 |
US19940253751 |
申请日期 |
1994.06.03 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY;THE REGENTS OF THE UNIVERSITY OF MICHIGAN;DANA-FARBER CANCER INSTITUTE |
发明人 |
JUNE, CARL H.;THOMPSON, CRAIG B.;NABEL, GARY J.;GRAY, GARY S.;RENNERT, PAUL D.;FREEMAN, GORDON J. |
分类号 |
C07K14/705;C07K16/28;(IPC1-7):A61K39/395;C07K16/00 |
主分类号 |
C07K14/705 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|