发明名称 |
Method for the site-specific modification of peptide alpha amines |
摘要 |
A peptide comprising a free terminal alpha amine is treated with an aryl sulfonamide activating agent, resulting in an activated amide. The resulting activated amide is deprotonated with a base and modified by the addition of a substituent group. The aryl sulfonamide activating group is cleaved using a nucleophilic substitution reaction. The method is particularly useful for the modification of peptides at specific N-alpha positions, and is compatible with conventional solid phase peptide synthesis, including those that utilize Fmoc protecting groups.
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申请公布号 |
US5859191(A) |
申请公布日期 |
1999.01.12 |
申请号 |
US19960761023 |
申请日期 |
1996.12.05 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MILLER, STEPHEN;SCANLAN, THOMAS S. |
分类号 |
A61P25/04;A61K38/00;A61P43/00;C07K1/04;C07K5/065;(IPC1-7):C07K1/08;G01N33/53;G01N33/543;G01N33/566 |
主分类号 |
A61P25/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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