发明名称 |
Non-A/non-B/non-C/non-D/non-E hepatitis agents and molecular cloning thereof |
摘要 |
Polypeptide antigens are disclosed which are immunoreactive with sera from individuals infected with non-A, non-B, non-C, non-D, non-E hepatitis. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic polypeptides. The antigens are useful in diagnostic methods for detecting the presence of N-(ABCDE) hepatitis agent infection in primates. The antigens are also useful in vaccine and antibody preparations. Methods are presented for the isolation of entire genomes corresponding to the N-(ABCDE) hepatitis agents.
|
申请公布号 |
US5859230(A) |
申请公布日期 |
1999.01.12 |
申请号 |
US19960611757 |
申请日期 |
1996.03.06 |
申请人 |
GENELABS TECHNOLOGIES, INC. |
发明人 |
KIM, JUNGSUH P.;REYES, GREGORY R.;YOUNG, LAVONNE MARIE |
分类号 |
A61K38/00;C07K14/18;(IPC1-7):C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|