Retroviral vector hybrids and the use thereof for gene transfer

摘要

PCT No. PCT/EP95/03175 Sec. 371 Date Mar. 7, 1997 Sec. 102(e) Date Mar. 7, 1997 PCT Filed Aug. 10, 1995 PCT Pub. No. WO96/07747 PCT Pub. Date Mar. 14, 1996Replication-defective retroviral vector hybrids which are characterized in that they contain a) the U5 region and/or tRNA primer binding site of MESV as the U5 region and/or tRNA primer binding site in the leader region and b) the U3 and R regions from a Friend murine leukaemia virus (F-MuLV) as the U3 and R regions in the 3'-LTR and which are particularly suitable for an effective gene transfer in haematopoietic stem cells.