| 摘要 |
PCT No. PCT/GB95/02190 Sec. 371 Date May 21, 1997 Sec. 102(e) Date May 21, 1997 PCT Filed Sep. 15, 1995 PCT Pub. No. WO96/08273 PCT Pub. Date Mar. 21, 1996A pharmaceutical composition comprises a solution or suspension of a biological agent in a diluent comprising D2O, which solution or suspension contains sufficient amounts of a sugar, phosphate, glutamic acid or a physiologically acceptable salt thereof and, optionally, a non-toxic protein, a peptone or a mixture of two or more amino acids besides glutamic acid to enhance the stability of the agent. Typically, the composition is a suspension of a live attenuated poliovirus or an inactivated poliovirus of each of poliovirus types 1, 2 and 3. Preferably the solution or suspension contains stabilising amounts of sucrose, KH2PO4, K2HPO4, L-glutamic acid or sodium glutamate and human serum albumin (SPGA).
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