CrystallineÄ-Ü 3R 4R-trans-7 methoxy 2,2-dimethyl 1-3-phenyl 1-4 Ä4-12 Äpyrrolidin-1 -Y1Üethoxyl 1Üchromane hydrogen fumarate

摘要

The present invention provides novel crystalline (-)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane, hydrogen fumarate useful for reducing or preventing bone loss as well as pharmaceutical compositions containing the same. A process for preparing (-)-3R,4R-trans-7-methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane, hydrogen fumarate is described.