Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents

摘要

The present invention provides compounds of formula (1) wherein: R is hydrogen or -C(O)-(CH2)m-Q, wherein Q is hydrogen or -COOH and m is an integer 1, 2, 3 or 4; R1, R5 and R6 are independently a C1-C6 alkyl group; R2, R3 and R4 are independently hydrogen or a C1-C6 alkyl group; Z is thio, oxy or a methylene group; A is a C1-C4 alkylene group; X is thio or oxy; and G1 and G2 are independently hydrogen, C1-C6 alkyl or -C(O)-(CH2)n-CH3 an n is an integer 0, 1, 2 or 3; or a pharmaceutically acceptable salt therof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.