Novel sulphated hyaluronic acid derivatives - useful as coatings for bio-materials such as catheters, blood bags, syringes, and surgical instruments

摘要

Novel sulphated hyaluronic acid derivatives (I) or their salts in which the glucosamine moieties are partially N-sulphated and optionally totally O-sulphated in position 6 are claimed. Also claimed are: (1) a pharmaceutical composition comprising (I) or its salt in association with another pharmacologically active substance and a carrier; (2) a biomaterial comprising (I) or its salt optionally in association with a polymer and optionally further biologically active substances; (3) a biomedical object comprising a bypass, venous catheter, shunt, catheter, guide channel, probe, cardiac valve, artificial tendon, bone or cardiovascular replacement, contact lens, soft tissue replacement, replacement of animal origin, blood oxygenator, artificial kidney, heart, pancreas, liver, blood bag, syringe, surgical instrument, filtration system, laboratory instrument, container for culture or for the regeneration of cells or tissues or support for peptides, proteins or antibodies, coated with (I) or its salt; and (4) (I) or its salt or a mixture of (I) and optionally pharmacologically active substance, for the preparation of pharmaceutical compositions.