发明名称 beta-HYDROXY ETHYLAMINIUM NICOTINATE DERIVATIVES HAVING ANTIISCHENIC ACTIVITY
摘要 FIELD: medicine. SUBSTANCE: novel chemical compounds, more particularly beta- hydroethylaminium-5- hydroxynicotinates of formula I: beta wherein R is CH<SB>2</SB>CH<SB>2</SB>OH(XC-1), CH<SB>3</SB>(XC-2), H(XC-3), said compounds have antiischemic activity. Desired compounds are prepared by reacting 5- hydroxynicotinic acid with corresponding aminoalkyls in the presence of solvent during heating operation. In experiments on animals, said compounds show high antiischemic activity and low toxicity. EFFECT: improved properties of the title compounds. 2 ex, 4 tbl
申请公布号 RU2124502(C1) 申请公布日期 1999.01.10
申请号 RU19930053674 申请日期 1993.11.23
申请人 AKTSIONERNOE OBSHCHESTVO ZAKRYTOGO TIPA "FARMAKOR" 发明人 SMIRNOV L.D.;KESAREV O.G.;GATSURA V.V.;SERNOV L.N.;RAGIMOV A.A.;ROZONOV JU.B.;BUROV JU.V.
分类号 C07D213/80;A61K31/455;A61P9/10;(IPC1-7):C07D213/80 主分类号 C07D213/80
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