发明名称 3'-MONOPHOSPHORYLATING OLIGONUCLEOTIDES
摘要 <p>3'-Monophosphorylating oligonucleotides are provided, which stability in serum and endocellular is markedly higher than that of non-modified oligonucleotides and a little higher than that of phosphorothioate-modified oligonucleotides demonstrated by studying them in vitro and cell, which ability to uptake by cell is higher than that of non-modified oligonucleotides and phosphorothioate-modified oligonucleotides. Its products of metabolic degradation do not have any toxycity and side effect, due to 3'-monophosphorylating oligonucleotides not containing non-natural modification elements. Therefore, when used as therapeutic agents, 3'-monophosphorylating oligonucleotides are more advantageous and safer than phosphorothioate-modified oligonucleotides.</p>
申请公布号 WO1999000401(P1) 申请公布日期 1999.01.07
申请号 CN1998000102 申请日期 1998.06.26
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