| 摘要 |
<p>The present invention relates to compounds of general formula (I) wherein: R and R' are independently selected from hydrogen, hydroxy, chlorine, bromine, iodine, fluorine, (C1-C6)alkyl, (C1-C4)alkoxy, (C1-C4)acyloxy, amino, mono-(C1-C4)alkylamino, di-(C1-C4)alkylamino, -SH, (C1-C4)alkylthio, carboxy, (C1-C4)alkoxycarbonyl groups; R1 and R1' are independently selected from hydrogen, hydroxy, hydroxymethyl, amino, carboxy, (C1-C4)alkyl groups; A is a phenyl or naphthyl group substituted by at least one group selected from hydroxy, carboxy, -SH, -CONHOH or -PO3H2 group, or is a 5- or 6-membered heterocycle containing one or two heteroatoms selected from oxygen, nitrogen or sulfur, which can be optionally benzocondensed and/or substituted by at least one group selected from pyridyl, -SH, -PO3H2, carboxy or CONHOH, or is a group of the formula -(CH2)n-X, in which n is zero or the integers 1 or 2, and X is selected from -SH, -PO3H2, -CONHOH, carboxy, amino, mono-(C1-C4)alkylamino, di-(C1-C4)alkylamino, enantiomers, diastereoisomers, racemates and mixtures thereof, as well as salts thereof with pharmaceutically acceptable acids and bases, as antitumor and antimetastatic agents.</p> |
